Aug 17, 2023 · In a 72-week carcinogenicity study, mice were administered daily doses of simvastatin of 25, 100, and 400 mg/kg body weight, which resulted in mean plasma drug levels approximately 1, 4, and 8 times higher than the mean human plasma drug level, respectively (as total inhibitory activity based on AUC) after an 80-mg oral dose
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Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be
Statins, one of the most extensively studied drugs on the planet, taken by tens of millions of Americans alone, have long had a perplexing side effect
Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg
Home Simvastatin Print Save Simvastatin Pronunciation: SIM-va-sta-tin Generic name: simvastatin Brand name: Zocor Drug class: Statins Medically reviewed
Simvastatin is indicated to: Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo
GoodRx Health Simvastatin (Zocor) is in a class of prescription medications called statins
Simvastatin is a medication used to treat high cholesterol (hyperlipidemia)
You may report side effects to FDA at 1-800-FDA-1088
Simvastatin is a prodrug and is hydrolyzed to its active β-hydroxyacid form, simvastatin acid, after administration
This drug causes dose-related myopathy which, Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks
Bilheimer DW
A total of 312 drugs are known to interact with ezetimibe / simvastatin : 57 major drug interactions (228 brand and generic names) 244 moderate drug interactions (634 brand and generic names) 11 minor drug interactions (56 brand and generic names) No known drug interactions
This medicine may help prevent medical problems (eg, heart or blood vessel problems, heart attacks, or strokes) caused by clogged blood vessels
Simvastatin Oral Suspension should be taken in the evening on an empty stomach [see CLINICAL PHARMACOLOGY ]
Simvastatin is on Marley Drug’s Wholesale Price List
It may be given to you for other reasons
The risk may be raised if your child has low thyroid function, kidney problems, or takes this drug with certain other drugs
About simvastatin Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking simvastatin with other medicines and herbal supplements Probabilistic sensitivity analyses indicated that at a willingness-to-pay threshold of SEK500,000/QALY, rosuvastatin 20 mg would be cost-effective for approximately 75%–85% of simulations relative to atorvastatin or simvastatin 40 mg
In 2011, the FDA announced changes for the safety labels of Simvastatin, because of increased risk of injury while taking the highest dose of 80 milligrams
Precautions
Simvastatin, the widely available statin drug used to treat high cholesterol and triglyceride levels, Among the simvastatin group, 73
4% posterior probability of superiority of simvastatin to
And they’re thought to be as safe and effective as the brand-name versions
Simvastatin has an average rating of 4